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Monday, May 4, 2020 | History

3 edition of G-protein coupled receptors found in the catalog.

G-protein coupled receptors

G-protein coupled receptors

methods express

  • 226 Want to read
  • 37 Currently reading

Published by John Wiley & Sons in Chichester, West Sussex, UK, Hoboken, NJ .
Written in English

    Subjects:
  • Cell receptors,
  • Ion channels

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by David Poyner and Mark Wheatley.
    ContributionsPoyner, David., Wheatley, Mark.
    Classifications
    LC ClassificationsQH603.C43 G67 2009
    The Physical Object
    Paginationp. cm.
    ID Numbers
    Open LibraryOL24116491M
    ISBN 109780470749142
    LC Control Number2009031411

    GPCRdb contains data, web tools and diagrams for G protein-coupled receptors. It stores a manual annotation of all GPCR crystal structures, the largest collections of receptor mutants and reference sequence alignments. The tools run directly in the web browser allowing for swift analysis of structures, sequence similarities, receptor relationships, homology models, drug Description: G protein-coupled receptor data, web . Learn more about G Protein-Coupled Receptors (GPCRs) including related products, articles and interactive pathways.

    The first part of the book is mainly concerned with G protein-coupled receptors and covers structural studies of conformational changes and binding sites, phosphorylation and desensitisation.   The NOOK Book (eBook) of the G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening by Elsevier Science at Barnes & Due to COVID, orders may be delayed. Thank you for your : Elsevier Science.

    G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors.   G Protein-Coupled Receptors in Immune Response and Regulation, Volume presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling Author: Elsevier Science.


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G-protein coupled receptors Download PDF EPUB FB2

About this book. G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses.

They play an important role in a variety of diseases from cancer and diabetes. This text provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCR).

Advances discussed include reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and Author: Sandra Siehler. G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological by: About this book G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents.

Research into GPCRs is therefore growing at a fast pace and the range of techniques that can be applied to GPCRs is vast and continues to grow. G Protein-Coupled Receptors. Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction.

G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad. G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses.

Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research.

Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction.

G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of by: This book assists with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and the development of tools for screening novel GPCR drugs, with sections on tweaking of ligands, bioluminescence and FRET, GPCR signaling properties, and subcellular compartmentalization.

Molecular Biology of G-Protein-Coupled Receptors Applications of Molecular Genetics to Pharmacology. Authors: Brann, M. Free Preview. Buy this book eB40 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free About this book.

Many different mammalian cell-surface receptors are coupled to a trimeric signal-transducing G protein.

As noted earlier, ligand binding to these receptors activates their associated G protein, which then activates an effector enzyme to generate Cited by: 2. G Protein-Coupled Receptors in Immune Response and Regulation, Volume presents emerging concepts related to the role of GPCRs in immune response and regulation.

Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling (RGS) proteins in the immune system, information on Kinin receptors.

Though there are hundreds of different G-protein coupled receptors, they all have the same basic structure: they all consist of a single polypeptide chain that threads back and forth seven times through the lipid bilayer of the plasma membrane.

Presently, more than receptors have been cloned and sequenced. The Handbook of Receptors and Channels is the first handbook series to present the enormous amount of new molecular biological receptor data in a practical and useful format. Each volume in this remarkable series will focus on a specific molecular superfamily of receptors.

Receptors that interact with G proteins (G protein coupled receptors or GPCRs) have common characteristics. GPCRs are single polypeptides which have 7 membrane-spanning α - helices. Over similar GPCR receptor genes are found in humans, each encoding a protein of similar topology, but which bind different ligands.

G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters.

Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge.

In The G Protein-Coupled Receptors Handbook, leading academic researchers comprehensively survey the many recent advances that have occurred in the GPCR field. The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological.

Chapter Two - Conformational Ensemble View of G Protein-Coupled Receptors and the Effect of Mutations and Ligand Binding Ravinder Abrol, Soo-Kyung Kim, Jenelle K. Bray, Bartosz Trzaskowski, William A.

Goddard. G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular ro: IPR The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development.

Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Dis. Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs).

Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features.The major role of G-protein-coupled receptors is to transmit signals into the cell (Chapter 6 Section D).They are characterized by seven transmembrane segments.

This class of membrane proteins can respond to a wide range of agonists, including photon, amines, hormones, neurotransmitters and proteins.G Protein-Coupled Receptors. By Vincenzo Sorrentino. Hardback $ This product is currently out of stock. ISBN Published December 5, by CRC Press Book Description.

This is the first single source to present this important topic from the points of view of many international experts. Chapters written by morphologists.